باز برنامه ریزی سلول سوماتیک در مسیر پیشرفت به سمت ایجاد سلول بنیادی پرتوان القایی به عنوان مدل بیماری اسکلرودرمی

Scleroderma- one of the important autoimmune diseases- leads to death of endothelial cells as one of the early events of this disease. The lack of repair after the loss of endothelial cells is observed in these patients and although, its cause has remained unknown. The development of effective treatments for many rheumatoid diseases requires a better understanding of the pathophysiological mechanisms involved in the disease. Because of physiological and anatomical and developmental differences between human and other species, a proper scleroderma animal model which represent all aspects of the disease has not been generated yet. So, making a patient-based system to mimic a developmental defect and evaluating its probable repair mechanism is considered as a necessity. For this reason, the development of a model system which can be an evaluation of molecular and developmental defects and also explain the possible repair mechanism, would be considered as a requirement. Like other studies, using patient-specific cell as a limitless source, could provide new hope for development of novel therapeutic approaches for patient with scleroderma.